increased expression – Communicable Diseases Research

The Peripheral Immune Landscape in a Patient with Myocarditis after the Administration of BNT162b2 mRNA Vaccine

Article

Published on 2022-10-312022-11-15
Journal: Molecules and cells
[Category] COVID19(2023년), SARS, 진단, 치료기술,

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

Article

Published on 2022-10-142022-11-16
Journal: Life Science Alliance
[Category] COVID19(2023년), SARS, 변종,

Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

Article

Published on 2022-10-052022-11-15
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] absence activated Activation aggregate aggregates analysed antiviral immunity Blood blood cell CD107a CD62P Cell cells changes in chemokines Cohort correlated COVID-19 COVID-19 disease COVID-19 patient cytokine Cytokines Cytometry cytotoxicity discharged disease pathology early stage Ex vivo Features flow cytometry form Frequency gene signature hospital hospitalised hospitalised COVID-19 patient ICU ICU patient IFN-γ IL-15 in vitro increased expression Infection innate immune response intensive care unit killing majority natural Neutrophils NK cell NK cells Patient patients phenotype phenotyped plasma Platelet platelet aggregates. Platelets Post-COVID-19 patients quantified SARS-CoV-2 scRNA-seq severe COVID-19 disease severe symptoms Single-cell RNA-sequencing Stage subset Symptom Symptoms target cells the timing TNF-α viral infections were measured while
[DOI] 10.3389/fimmu.2022.861251 PMC 바로가기

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

Article

Published on 2022-09-062022-11-15
Journal: PLoS Pathogens
[Category] SARS, 치료제,

Novel application of [18F]DPA714 for visualizing the pulmonary inflammation process of SARS-CoV-2-infection in rhesus monkeys (Macaca mulatta)

Article

Published on 2022-09-012022-11-16
Journal: Nuclear medicine and biology
[Category] COVID19(2023년), SARS, 치료기술,

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

일본 COVID-19 태스크포스의 465개 COVID-19 감염 샘플의 전혈 전사 조절 풍경

Article

Published on 2022-08-222022-09-11
Journal: Nature Communications
[Category] 변종, 유전자 메커니즘,

[키워드] Analysis caused CLEC4C coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 infected individual COVID-19 infection COVID-19 phenotype COVID-19 severity deaths Differential gene expression differential gene expression analysis disease eQTL eQTLs evaluate example expression expression quantitative trait loci force functions Gene Expression genotyped highlight increased expression independent Infectious disease Japan Japanese loci mechanism MYBL2 phenotype provide QTL Quantitative Regulation Regulatory REST RNA-seq data severe COVID-19 single variant splice STING1 Task Force TOR1AIP1 transcriptional transcriptional regulation variant Whole blood
[DOI] 10.1038/s41467-022-32276-2 PMC 바로가기 [Article Type] Article

Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall

Research

Published on 2022-08-112022-10-05
Journal: Scientific Reports
[Category] 유전자 메커니즘,

Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2

새로운 인간 코로나바이러스 SARS-CoV, MERS-CoV 및 SARS-CoV-2에 대한 면역 반응 유도를 위한 3가 서브유닛 백신을 설계하기 위해 높은 처리량 및 포괄적인 면역정보학 접근법 적용

Article

Published on 2022-08-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] SARS, 치료법,

[키워드] acute respiratory syndrome added adjuvant against SARS-CoV analysis Antigen antigens applied Applying approach approach B-cell binding affinity codon optimization complex conducted coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs CTL defensin demonstrated disease docking epitope Epitopes facilitate HLA HTL HTLs human coronavirus IEDB IFN IFN-γ immune response immune responses immunogenic immunoinformatics In silico cloning increased expression kDa MDs membrane MERS MERS-CoV MERS‐CoV MHC I Middle East Middle East respiratory syndrome molecular dynamics Molecular dynamics simulation molecular weight molecule Multi-epitope vaccine non-allergenic non-structural protein nucleocapsid PADRE Pan predicted Protein responses SARS-CoV SARS-CoV-2 SARS‐CoV secondary selected epitope sequence sequences Severe acute respiratory syndrome stability stimulate Structure subunit Subunit vaccine Subunit vaccine. syndrome T lymphocyte TAT the vaccine trivalent Vaccine was used β-defensin
[DOI] 10.1080/07391102.2021.1876774 PMC 바로가기 [Article Type] Article

Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes

임신성 SARS-CoV-2 감염은 면역 및 영양막 유전자의 태반 발현과 관련이 있습니다

Article

Published on 2022-08-012022-09-11
Journal: Placenta
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] absence age analysis antibody Birth CGB3 change contribute correlation CXCL10 DDX58 decreased expression during pregnancy Effect evaluate expression feature Features fetus Fisher Gene Expression Generation gestational age group groups Health histologic Histopathology IgG IgG antibody immune immune gene immune genes increased expression Infant Infants Linear regression linear regression models Maternal median molecular Mount Sinai Mount Sinai Health System NanoString nasal swab New York City no significant differences not differ offspring outcome participant Participants performed Placenta placental Placentas positive positive RT-PCR Pregnancy pregnant prospective cohort study PSG3 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2. serology test severe disease significant difference significant differences Spearman statistical analyses System term the SARS-CoV-2 TLR3 Transmission vertical transmission
[DOI] 10.1016/j.placenta.2022.06.017 PMC 바로가기 [Article Type] Article

BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein

SARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein spike protein. stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus virus VoC VSV VSV (vesicular stomatitis virus)
[DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article